Protective effect of Capsosiphon fulvescens on oxidative stress-stimulated neurodegenerative dysfunction of PC12 cells and zebrafish larva models

Reactive oxygen species (ROS) at high concentrations induce oxidative stress, an imbalanced redox state that is a prevalent cause of neurodegenerative disorders. This study aimed to investigate the protective effect Capsosiphon fulvescens (CF) extract on stress-induced impairment cognitive function in models diseases. CF was extracted with subcritical water and several solvents H2O2 (0.25 mM) or aluminum chloride (AlCl3; 25 μM) as inducer ROS treated PC12 neuronal cells zebrafish larvae. All statistical analyses were performed using one-way analysis variance Dunnett’s test GraphPad Prism. AlCl3 found significantly production In addition, they strongly affected intracellular Ca2+ levels, antioxidant enzyme activity, brain-derived neurotrophic factor (BDNF) tropomyosin receptor kinase B (TrkB) signaling, acetylcholinesterase (AChE) hallmarks Alzheimer’s disease. However, treatment H2O2-induced AlCl3-induced larvae 90°C effectively regulated excessive production, mRNA expression superoxide dismutase, glutathione peroxide, glycogen synthase kinase-3 beta, β-amyloid, tau, AChE, BDNF, TrkB. Our suggested extracts can be potential source nutraceuticals improve synaptic plasticity by regulating generation